桂利嗪(cinnarizine, 脑益嗪)已广泛用于脑血管疾病、冠状动脉硬化症等的治疗,其副作用偶有嗜睡、皮疹、胃肠道反应等,但致男性乳房女性化少见,现将笔者采用山东济宁第三制药厂生产的桂利嗪引起的男性乳房女性化2例报告如下。 例1,男,61yr,厂医。患高血压、脑动脉硬化12yr,冠心病2mo余,于1989年10月6日入院。以往无乳房增大及过敏史。入院后给以卡托普利(captopril),硝酸异山梨酯(isosorbide dinitrate,消心痛),美西律(mexiletine, 慢心律),肠溶阿司匹林等药物治疗,病情稳定,未发现副作用。入院d3加服桂利嗪(批号为890321)25mg, tid, po, 服用2mo余,患者感双侧乳房胀痛,对称性增大,大小约 Cinnarizine (cinnarizine, brain Yizi) has been widely used in the treatment of cerebrovascular disease, coronary atherosclerosis and other side effects of occasional drowsiness, rash, gastrointestinal reactions, but to the feminization of the male breast rare, will now The author uses the third pharmaceutical factory in Jining, Shandong cinnarizine male breast feminization caused by 2 cases are as follows. Example 1, male, 61yr, factory doctor. Suffering from hypertension, cerebral arteriosclerosis 12yr, coronary heart disease more than 2mo, was admitted on October 6, 1989. In the past no breast enlargement and allergy history. After admission, captopril, isosorbide dinitrate (isosorbide dinitrate), mexiletine (mexiletine), enteric-coated aspirin and other drugs were given and were in stable condition with no side effects. Admission d3 plus take cinnarizine (batch number 890321) 25mg, tid, po, taking more than 2mo, patients with bilateral breast pain, increased symmetry, the size of about