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由于前列腺素参与人和动物的炎症、发热、休克和败血症这样一些病理一生理反应的发生发展过程,所以它在传染病的发病机制中起着重要的作用。已经证明,细菌的脂多醣可活化前列腺素前身的花生四烯酸和其它不饱和脂肪酸的环加氧酶(Cyclooxy-genase)和脂加氧酸(lypoxygenase)的代谢途径。内毒素血症、毒素在组织中直接运行,可导致这一组化合物在血浆中和许多器官中堆积。本文研究了用属于复杂的脂多醣-蛋白复合物的鼠疫“小鼠毒素”使大鼠中毒时在不同器官和血浆中前列腺素(PG)的动态含量。
Prostaglandin plays an important role in the pathogenesis of infectious diseases because it participates in some pathophysiological and physiological processes such as inflammation, fever, shock and sepsis in humans and animals. It has been demonstrated that bacterial lipopolysaccharides can activate the metabolic pathways of cyclooxygenase and lypoxygenase of arachidonic acid and other unsaturated fatty acids of prostaglandin. Endotoxemia, toxin directly in the organization, can lead to the accumulation of this group of compounds in many organs and plasma. In this paper we investigated the dynamic content of prostaglandin (PG) in different organs and plasma when rats were poisoned with plague mice “mice toxins” belonging to the complex lipopolysaccharide-protein complex.