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血清素(Serotonin)是近年来新发现的激素。它是体内极为重要的神经内分泌传递因子,具有異常广泛的生理作用,是维持机体特别是脑组织正常活动的重要物质。在临床上血清素参与多种疾病的发病机制,并可利用它的代谢拮抗物以治疗某些疾病,因而越来越被生理、药理及临床学家所重视。血清素的前身是色氨酸,其最终代谢产物5—羟吲(口朶)醋酸(简称5HIAA)由尿液排泄。尿中5HIAA排量的测定对于了解与血清素有关的生理和病理状态具有重要的意义。关于尿中5HIAA的测定,国内尚未见有专门论述,本文按Udenfrien(?)等的方法,结合我们的实验结果报导干下,以供参考。
Serotonin is a newly discovered hormone in recent years. It is an extremely important neuroendocrine delivery factor in the body and has an unusually wide range of physiological functions. It is an important substance for maintaining the normal activity of the body, especially the brain tissue. In clinical practice, serotonin is involved in the pathogenesis of various diseases and can utilize its metabolic antagonists to treat certain diseases. Therefore, serotonin is increasingly valued by physiology, pharmacology and clinical scientists. Serotonin is the predecessor of tryptophan, the final metabolite 5 - hydroxyindole (mouth) acetic acid (5HIAA) excreted by the urine. The determination of 5HIAA in urine is of great importance for understanding the physiological and pathological conditions associated with serotonin. For the determination of 5HIAA in urine, there is no specific discussion in China. According to the method of Udenfrien (?) Et al.