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目的探讨益生菌联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。方法选取泉州市第一医院2012年4月—2014年10月收治的NAFLD患者73例,随机将患者分为对照组31例与治疗组36例。对照组患者予多烯磷脂酰胆碱治疗,治疗组患者在对照组基础上予以双歧杆菌乳杆菌三联活菌片治疗,两组患者均连续治疗12周。比较两组患者临床疗效、临床症状改善情况、治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)]和血脂指标[三酰甘油(TG)、总胆固醇(TC)]及不良反应发生情况。结果治疗组总有效率高于对照组(P<0.05)。治疗组患者腹胀改善情况优于对照组(P<0.05);两组患者肝区疼痛、乏力改善情况比较,差异无统计学意义(P>0.05)。治疗前两组患者ALT、AST、TG、TC水平比较,差异无统计学意义(P>0.05);治疗后治疗组TG、TC水平低于对照组(P<0.05);治疗后两组患者ALT、AST水平比较,差异无统计学意义(P>0.05)。治疗组患者出现双下肢皮疹1例。结论益生菌联合多烯磷脂酰胆碱治疗NAFLD的临床疗效确切,可有效改善患者症状、血脂及肝功能。
Objective To investigate the clinical efficacy of probiotics combined with polyene phosphatidylcholine in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods 73 patients with NAFLD admitted to the First Hospital of Quanzhou from April 2012 to October 2014 were randomly divided into control group (31 cases) and treatment group (36 cases). Patients in the control group were treated with polyene phosphatidylcholine. Patients in the treatment group were treated with Lactobacillus bifidosis triple viable bacteria on the basis of the control group, and both groups were treated continuously for 12 weeks. The clinical curative effect and clinical symptom improvement were compared between the two groups. The liver function index (ALT, AST) and the level of serum lipids (triglyceride, triglyceride, Total cholesterol (TC)] and adverse reactions occurred. Results The total effective rate of the treatment group was higher than that of the control group (P <0.05). The improvement of abdominal distension in the treatment group was better than that of the control group (P <0.05). There was no significant difference between the two groups in improving the pain and fatigue in the liver area (P> 0.05). There was no significant difference in ALT, AST, TG and TC levels between the two groups before treatment (P> 0.05). After treatment, the levels of TG and TC in the treatment group were lower than those in the control group (P <0.05) , AST levels, the difference was not statistically significant (P> 0.05). The treatment group patients with double lower extremity rash in 1 case. Conclusion Probiotics combined with polyene phosphatidylcholine treatment of NAFLD clinical curative effect, can effectively improve the symptoms, blood lipids and liver function.