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内柯萨奇病毒感染患儿、医护人员以及哺乳的产妇均可成为本病散发或流行的传染源。20世纪70年代初已报道病毒可经胎盘传播,而且认为与先天性心血管畸形有关。Brown和Karunas等(1970年)对630名各类畸形婴儿母亲用中和试验检测针对CVB1～CVB5的抗体,结果发现母亲于妊娠早期受CVB3
Children with Coxsackie virus infection, health care workers and breastfeeding mothers can become the source of infection or epidemic of the disease. It has been reported in the early 1970s that the virus can be transmitted via the placenta and is thought to be associated with congenital cardiovascular malformations. Brown and Karunas et al. (1970) tested antibodies against CVB1-CVB5 in neutralized mothers of 630 all-manner malformed mothers and found that mothers were affected by CVB3