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目的通过Meta分析的方法探讨PET或PET/CTSUV值对头颈部鳞癌预后的影响。方法检索PubMed、EM-BASE、Cochrane图书馆、CBM、CNKI和重庆维普等数据库,收集有关PET或PET/CTSUV值对头颈部鳞癌预后影响的病例进行对照研究,对纳入的研究进行质量评价,提取有效数据,采用RevMan4.2.8软件对总生存率(OS)、无病生存率(DFS)和局部控制率(LC)等进行Meta分析。结果共纳15个研究,包括461例患者。分析结果显示:高SUV值组和低SUV值组比较,2、3、5年的总生存率RR值及95%CI分别为0.66(0.55～0.80)、0.65(0.55～0.76)、0.49(0.33～0.72);无病生存率RR值及95%CI分别为0.70(0.62～0.79)、0.59(0.52～0.67)、0.65(0.49～0.86);局部控制率RR值及95%CI分别为0.76(0.66～0.88)、0.75(0.67～0.84)、0.52(0.33～0.85),差异均具有统计学意义(P<0.05)。结论 SUV值可能是头颈部鳞癌的独立预后因素,但须进一步开展多中心前瞻性随机对照研究,以确定SUV值的预后相关阈值及其临床指导意义。
Objective To investigate the effect of PET or PET / CTSUV values on the prognosis of head and neck squamous cell carcinoma by Meta-analysis. Methods The databases of PubMed, EM-BASE, Cochrane Library, CBM, CNKI and Chongqing Vipu were searched to collect the data of PET or PET / CTSUV values on the prognosis of head and neck squamous cell carcinoma. The quality of the included studies was evaluated, Effective data were extracted and Meta-analysis was performed using RevMan 4.2.8 software on overall survival (OS), disease-free survival (DFS) and local control rate (LC). Results A total of 15 studies were included, including 461 patients. The results showed that the RR and 95% CI of 2, 3 and 5 years were 0.66 (0.55-0.80), 0.65 (0.55-0.76) and 0.49 (0.33) respectively in high SUV group and low SUV group ~ 0.72) .The RR and 95% CI of disease-free survival were 0.70 (0.62-0.79), 0.59 (0.52-0.67) and 0.65 (0.49-0.86) respectively. The RR and 95% CI of local control were 0.76 0.66 ~ 0.88), 0.75 (0.67 ~ 0.84) and 0.52 (0.33 ~ 0.85), respectively, with statistical significance (P <0.05). Conclusions The SUV value may be an independent prognostic factor for head and neck squamous cell carcinoma. However, a prospective multicenter prospective randomized controlled study should be conducted to determine the prognostic relevance of SUV and its clinical significance.