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作者测定了新生儿硬肿症患儿45例及健康新生儿13例血浆中血栓素B_2(TXB_2)、6-酮前列腺素F_(1α)(6-keto-PGF_(1α))及血清磷脂酶A_2(PLA_2)的水平变化.前者血浆TXB_2水平Ⅱ度,Ⅲ度硬肿均明显较对照组高(P<0.05及0.01),而Ⅱ度,Ⅲ度之间无明显差别.TXB_2与体温间呈负相关关系.6-keto-PGF_(1α)及PLA_2浓度Ⅲ度硬肿皆明显高于Ⅱ度硬肿及对照组(P<0.01),且肺出血患儿二者明显高于无肺出血者(P<0.01).本结果首次证实PLA_2的激活及PGI_2与TXB_2的失衡在新生儿硬肿症及其肺出血的发生发展中起重要作用.为今后应用环氧化酶抑制剂及PLA_2抑制剂防治新生儿硬肿症和肺出血提供了理论依据.
The authors determined the levels of plasma TXB_2, 6-keto-PGF_ (1α) and serum phospholipase in 45 neonates with SCD and 13 healthy newborns A_2 (PLA_2) levels in the former were significantly higher than those in the control group (P <0.05 and 0.01), while there was no significant difference between the second degree and the third degree (P <0.01), and both of the patients with pulmonary hemorrhage were significantly higher than those without pulmonary hemorrhage (P <0.01) .6-keto-PGF_ (1α) and PLA_2 third degree of edema were significantly higher than those of second degree edema and the control group (P <0.01) .The results for the first time confirmed the activation of PLA_2 and imbalance of PGI_2 and TXB_2 play an important role in the development of neonatal sclerema and pulmonary hemorrhage.For the future application of cyclooxygenase inhibitors and PLA_2 inhibitors Provide a theoretical basis for the prevention and treatment of neonatal scleredema and pulmonary hemorrhage.