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棉籽粉对雄性大鼠有抗生育作用,其有效成份为棉酚。棉酚对雄性大鼠的抗生育作用最低有效剂量为10～12mg/kg,连续给药4～5周。停药后4～5周生育力能可逆恢复。棉酚对大鼠的交配行为及副性腺的功能均无明显的影响;亦不改变大鼠及猴血浆中睾丸酮的含量。棉酚对子代生长及生育力均无不良影响。大鼠长期服用棉酚后,心电图未见有异常变化。部分大鼠的血清谷丙转氨酶及γ球蛋白值稍有升高,停药后恢复正常。个别大鼠肝组织切片显于肝细胞有病理性改变。右旋棉酚既无明显的抗生育作用,亦无显著的毒性反应,提示棉酚的抗生育作用及毒性反应与左旋体有关。棉酚结构上的CHO基与OH基,一旦用其它基团取代,即失去抗生育作用。
Cottonseed meal on male rats have anti-fertility effects, the active ingredient is gossypol. The lowest effective dose of gossypol on male rats is 10 ~ 12mg / kg, continuous administration for 4 ~ 5 weeks. 4 to 5 weeks after stopping fertility reversible recovery. Gossypol had no significant effect on the mating behavior and the function of the gonads in rats, and did not change the testosterone levels in the plasma of rats and monkeys. Gossypol had no adverse effects on the growth and fertility of offspring. Long-term use of gossypol in rats, the ECG showed no abnormal changes. Some rats serum alanine aminotransferase and gamma globulin values slightly increased, returned to normal after withdrawal. Individual rat liver tissue sections showed pathological changes in liver cells. There was no obvious anti-fertility effect and no significant toxicity, suggesting that the anti-fertility and toxicity of gossypol were related to L-type. Gossypol structure of CHO and OH groups, once replaced with other groups, that is, loss of anti-fertility.