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四氢小檗碱(tetrahydroberberine,dl-THB)来源于罂粟科紫堇属植物延胡索(Corydalis yanhusuoW.T.Wang)的块根,属四氢异喹啉类生物碱。四氢小檗碱具有镇静、镇痛、催眠、降压等药理作用[1]。四氢小檗碱的化学结构上有一个手性中心,图1,研究表明,手性药物的单个对映体在体内的吸收、分布、代谢以及排泄等环节中,常因与机体内的具有高度立体特异性的生物大分子相互作用等,表现出不同的药动学特征,具有立体专一性[2]。吸收是药物发挥药效的
Tetrahydroberberine (dl-THB) is derived from the root of Corydalis yanhusuoW.T.Wang, belonging to the genus Papaveraceae. It is a tetrahydroisoquinoline alkaloid. Tetrahydroberberine has sedative, analgesic, hypnotic, antihypertensive and other pharmacological effects [1]. Tetrahydroberberine has a chemical structure chiral center, Figure 1, studies have shown that the individual enantiomers of chiral drugs in vivo absorption, distribution, metabolism and excretion and other links, often due to the body with Highly stereospecific biological macromolecular interactions, showing different pharmacokinetic characteristics, with three-dimensional specificity [2]. Absorption is the drug play a role