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目的:探讨米索前列醇不同给药途径终止妊娠的效果。方法:选取我院2011年6月至2013年6月行终止妊娠的100例孕产妇为研究对象,根据用药方式不同将其随机分为两组,观察组患者采取米索前列醇阴道放置治疗,对照组患者行米索前列醇口服治疗,对两组患者治疗效果进行比较。结果:观察组患者宫颈软化显效40例(80%),有效8例(16%),总有效率96%;对照组患者宫颈软化显效20例(40%),有效18例(36%),总有效率76%。观察组患者宫颈软化总有效率明显高于对照组,差异有统计学意义,P<0.05。此外,两组患者在疼痛程度、不良反应情况等上差异有统计学意义,P<0.05。结论:与米索前列醇口服比较,阴道给药具有宫颈软化更充分、缓解疼痛、不良反应较少等优点,可作为米索前列醇终止妊娠的首选给药途径。
Objective: To investigate the effect of misoprostol on the termination of pregnancy by different routes of administration. Methods: A total of 100 pregnant women who terminated their pregnancy from June 2011 to June 2013 in our hospital were selected as study subjects. They were randomly divided into two groups according to the method of administration. The patients in the observation group were treated with vaginal misoprostol, Patients in the control group were treated with misoprostol orally, and the treatment effect was compared between the two groups. Results: In the observation group, 40 cases (80%) were effective in cervical softening, 8 cases (16%) were effective, and the total effective rate was 96%. In the control group, 20 cases (40% The total efficiency of 76%. The total effective rate of cervical softening in observation group was significantly higher than that of control group, the difference was statistically significant, P <0.05. In addition, the two groups of patients in the degree of pain, adverse reactions and other differences were statistically significant, P <0.05. Conclusion: Compared with the oral administration of misoprostol, vaginal administration has the advantages of more complete cervical softening, pain relief and fewer adverse reactions, which can be used as the preferred route of administration for misoprostol termination of pregnancy.