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I及i抗原首先在红细胞上被发现,随后在淋巴细胞和其它细胞上亦发现。与红细胞上的i抗原不同,在整个成年期,淋巴细胞上的i抗原很容易被测定。正常的B和T淋巴细胞上具有同样多的i抗原。而慢性淋巴细胞白血病(CLL)患者血液的淋巴细胞上的i抗原较正常人明确降低。为了确定淋巴细胞i抗原的测定是否能鉴别淋巴肉瘤细胞性白血病(LSL)和CLL,以及能否区别早期的CLL病人和因其它原因引起的淋巴细胞增多
I and i antigens were first found on erythrocytes and subsequently on lymphocytes and other cells. Unlike i antigens on red blood cells, i antigens on lymphocytes can be readily measured throughout adulthood. There are as many i antigens on normal B and T lymphocytes. In patients with chronic lymphocytic leukemia (CLL), the blood lymphocytes i antigen was significantly lower than normal. In order to determine whether the determination of lymphocyte i antigens can discriminate between lymphosarcoma leukemia (LSL) and CLL, and whether it is possible to distinguish between early CLL patients and lymphocytosis caused by other causes