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目的 :观察血管紧张素转换酶抑制剂 (ACEI)对老年急性心肌梗死 (AMI)心率变异性 (HRV)的影响 ;方法 :6 4例老年急性心肌梗死患者随机分为二组 ,一组为常规治疗 ,一组为加服西拉普利 ( 5 2～ 5mg 1次 /d)共 4周 ,并于心肌梗死后 48h、4周测HRV指标。同时测 30例健康老年人HRV指标作为对照 ;结果 :二组急性心肌梗死患者 48hHRV指标差异不显著 ,但均低于对照组 ,差异非常明显 (P <0 0 1 ) ,心肌梗死后 4周二组HRV指标均高于 48h ,差异显著 (P <0 0 5 ) ,且西拉普利组高于常规治疗组 (P <0 0 5 )。但均低于对照组 (P <0 0 5 ) ;结论 :老年急性心肌梗死患者HRV值明显降低 ,西拉普利可以明显提高HRV指标
Objective: To observe the effect of angiotensin converting enzyme inhibitor (ACEI) on heart rate variability (HRV) in elderly patients with acute myocardial infarction (AMI). Methods: Sixty-four elderly patients with acute myocardial infarction were randomly divided into two groups, One group was given Cilazapril (5 2 ~ 5mg once a day) for 4 weeks, and 48 hours after myocardial infarction, 4 weeks measured HRV. At the same time, the HRV indexes of 30 healthy elderly people were taken as the control. Results: The 48hHRV indexes of two groups of patients with acute myocardial infarction were not significantly different (all P <0.01), but were significantly lower than those of the control group HRV indexes were higher than 48h, the difference was significant (P <0 05), and Cilazapril group than the conventional treatment group (P <0 05). But both were lower than those in the control group (P <0.05). Conclusion: The HRV of elderly patients with acute myocardial infarction was significantly lower than that of cilostazol group