论文部分内容阅读
目的观察脑梗死病人血浆同型半胱氨酸与脑梗死的关系及其临床意义。方法 79例急性脑梗死患者和同期39例对照者采用荧光偏振免疫分析法测定空腹血浆同型半胱氨酸,采用化学发光法测定叶酸和维生素 B_(12)。结果血浆同型半胱氨酸(Hcy)>15μmol/L 者,脑梗死组为57例,占71.25%。对照组为5例,占12.5%。两组平均 t-Hcy 分别为22.40±11.23 μmol/L和11.89±2.50 μmol/L,差异有极显著性(X~2=36.87,P<0.01)。叶酸水平:两组分别为4.73±1.83 ng/mL 与(6.77±4.29)ng/mL,(t=3.62,P<0.01);维生素 B_(12)水平:两组分别为5.59±0.73 pg/mL 与5.96±0.56 pg/mL,(t=2.78,P<0.01);差异均有极显著性。结论脑梗死病人血浆同型半胱氨酸水平是升高的,而叶酸和维生素 B_(12)水平呈下降。
Objective To observe the relationship between plasma homocysteine and cerebral infarction in patients with cerebral infarction and its clinical significance. Methods Fasting plasma homocysteine was determined by fluorescence polarization immunoassay in 79 patients with acute cerebral infarction and 39 controls at the same time. The levels of folic acid and vitamin B 12 were determined by chemiluminescence assay. Results Plasma homocysteine (Hcy)> 15μmol / L, cerebral infarction group was 57 cases, accounting for 71.25%. The control group was 5 cases, accounting for 12.5%. The average t-Hcy in the two groups was 22.40 ± 11.23 μmol / L and 11.89 ± 2.50 μmol / L, respectively. The difference was significant (X ~ 2 = 36.87, P <0.01). Folic acid levels were 4.73 ± 1.83 ng / mL and 6.77 ± 4.29 ng / mL in the two groups (t = 3.62, P <0.01). Vitamin B 12 levels were 5.59 ± 0.73 pg / mL And 5.96 ± 0.56 pg / mL, (t = 2.78, P <0.01). The differences were significant. Conclusions Plasma homocysteine levels are elevated in patients with cerebral infarction, while folic acid and vitamin B 12 levels are decreased.