用免疫放射分析（ＩＲＭＡ）检测接受白细胞介素－２（ｒＩＬ－２）治疗的肿瘤病人血清标本中ＩＬ－２活性。该法采用双抗体夹心模式，灵敏度＜２．１Ｕ／ｍｌ，（２９０ｎｇ／ｍｌ），平均批内和批间变异系数分别为１．９８％和５．２７％，方法特异、灵敏、快速。用此法检测两组皮下注射不同剂量ｒＩＬ－２的１６例本院肿瘤病人血清浓度，并对部分病例进行药代动力学研究，其血药浓度变化曲线属二室模型。消除半衰期（ｔ１／２β）为１８ｈ，达峰时间为２．５ｈ。 IL-2 activity in sera from patients with tumor treated with interleukin-2 (rIL-2) was measured by immuno-radiometric analysis (IRMA). The method of double-antibody sandwich mode, the sensitivity of <2.1U / ml, (290ng / ml), the average intra-batch and inter-batch coefficient of variation were 1.98% and 5.27%, the method is specific, sensitive and fast. This method was used to test the serum concentrations of 16 patients with different concentrations of rIL-2 injected subcutaneously in two groups. The pharmacokinetics of some patients were also studied. The curve of plasma concentration of two groups was a two-compartment model. Elimination half-life (t1 / 2β) for 18h, peak time of 2.5h.