目的　探索检测中早期非小细胞肺癌外周血微转移的理想途径以及手术对促进微转移的影响。方法　对 2 0例可手术的中早期非小细胞肺癌分别于术前、手术刚结束、术后一周取外周血 ,用RT PCR法检测肺癌特异性基因LUNX的表达情况 ,并与肺部良性疾病患者外周血LUNX基因的表达进行对比。结果　在被检测的 2 0例患者中 ,有 9例在不同时期被检测到有LUNX基因表达 ,而肺部良性疾病患者外周血均未发现LUNX基因表达。结论　RT PCR法检测外周血LUNX mRNA是理想的诊断非小细胞肺癌微转移的方法 ;手术治疗可以减少肺癌患者术后远处转移的发生 ;手术操作可能促进肿瘤细胞向外周血的脱落 Objective To explore the ideal way to detect peripheral micrometastasis in early-stage non-small cell lung cancer (NSCLC) and the effect of surgery on micrometastasis. Methods Twenty 20 patients with operable early-stage non-small cell lung cancer (NSCLC) were enrolled in this study. The operation was completed just before operation and one week after operation. The expression of LUNX gene in lung cancer was detected by RT-PCR. Patients with peripheral blood LUNX gene expression comparison. RESULTS: Of the 20 patients tested, 9 were found to have LUNX gene expression at different times, while none of the patients with benign lung disease had LUNX gene expression. Conclusion The detection of LUNX mRNA in peripheral blood by RT-PCR is an ideal method to diagnose micrometastasis of non-small cell lung cancer. Surgical treatment can reduce the distant metastasis of lung cancer patients after operation. Surgery may promote the shedding of tumor cells to peripheral blood