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目的探讨腮腺炎致无精子症患者抑制素B水平的关系及临床意义。方法 38例腮腺炎致无精子症患者,经睾丸切开取精(TESE),显微镜下观察能否找到活动的精子,采用化学发光免疫分析法测定血清FSH浓度,ELISA测定血清抑制素水平。结果腮腺炎TESE无精子症患者与TESE获得精子组和对照组相比,血清FSH水平显著升高(P<0.01),抑制素B水平显著降低(P<0.01)。TESE获得精子组与对照组相比,血清FSH水平升高,但无显著差异(P>0.05);抑制素B水平轻微下降。结论血清FSH水平结合抑制素水平的可作为预测无精子症的无创检测指标之一。
Objective To investigate the relationship and clinical significance of inhibin B in patients with mumps-induced azoospermia. Methods 38 cases of mumps-induced azoospermia were examined by testicular septicemia (TESE). The presence of active sperm was observed under a microscope. Serum FSH concentrations were measured by chemiluminescence immunoassay and serum inhibin levels were determined by ELISA. Results Compared with TESE sperm group and control group, the level of serum FSH was significantly increased (P <0.01) and that of inhibin B was significantly decreased (P <0.01). Serum FSH levels were higher in the TESE sperm group than in the control group but not in the sperm group (P> 0.05), while the level of inhibin B decreased slightly. Conclusion Serum FSH levels combined with inhibin levels can be used as a noninvasive index to predict azoospermia.