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目的 :探讨脑卒中患者血浆 5 -羟色胺 ( 5 -HT)及其相关物质的变化与临床的关系。方法 :用荧光法测定 5 0例急性脑卒中患者和 5 0例健康者血浆 5 -HT,5 -羟吲哚乙酸 ( 5 -HIAA) ,去甲肾上腺素 ( NE)水平。结果 :急性脑卒中血浆 5 -HT,5 -HIAA,NE水平显著高于健康组 ( P<0 .0 0 1 ) ,脑出血组 5 -HT升高更为显著 ,脑卒中死亡患者 5 -HT显著高于存活者 ( P<0 .0 1 )。结论 :本研究提示血浆 5 -HT升高反映了急性脑卒中的严重程度。
Objective: To investigate the relationship between the changes of 5-hydroxytryptamine (5-HT) and related substances in patients with stroke and its clinical significance. Methods: The plasma levels of 5-HT, 5-HIAA and NE in 50 acute stroke patients and 50 healthy controls were measured by fluorometry. Results: The levels of 5-HT, 5-HIAA and NE in acute stroke were significantly higher than those in healthy group (P <0.01). The 5-HT increased more significantly in cerebral hemorrhage group. The 5-HT Significantly higher than those of survivors (P <0.01). Conclusion: This study suggests that plasma 5-HT elevation reflects the severity of acute stroke.