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天津市卫生局于1981年12月8～9日在天津主持召开了L-天门冬氨酸钾镁盐技术鉴定会。参加会议的有北京、天津、辽宁等省市有关代表30人。 L-天门冬氨酸钾镁盐是用于治疗各种原因引起的低血钾症及多种心血管疾病的新药。国外已用于临床,但尚未纳入药典。天津市药物研究所于1976年研制成功,药理实验表明,该药以与细胞亲和力较强的天门冬氨酸为载体,可提高血清细胞内钾、镁离子浓度,能明显增强实验动物对常压和减压的缺氧耐力,对实验性心肌缺血坏死和心肌重要酶系有良好的保护作用,并能对抗实验性药物引起的心律失常。临床试用证明,国产L-天门冬氨酸钾镁盐对低钾症及低钾、洋地黄中毒引起的心律失常等均有较好疗效。经北京、天津、辽宁等省市11个临床单位试用,共总结189例,总有效率为77.8%,其中对各种原因引起的低血钾症疗效显著,有效率达86.9%,对于低钾及洋地黄中毒引起的心律失常等,有效率为81.8%,对其它原因引起的心律失常作为辅助药物也有一定疗效。
Tianjin Health Bureau in December 1981 8-9 held in Tianjin, L-aspartate potassium and magnesium salt technical appraisal meeting. There were 30 delegates from Beijing, Tianjin and Liaoning provinces participating in the conference. L-aspartate potassium magnesium salt is used for the treatment of various causes of hypokalemia and a variety of cardiovascular disease new drugs. Foreign has been used in clinical, but not yet included Pharmacopoeia. Tianjin Institute of Materia Medica was successfully developed in 1976, pharmacological experiments show that the drug with strong affinity aspartate as a carrier, can increase serum potassium, magnesium ion concentration, can significantly enhance the experimental animals to normal pressure And decompression endurance of hypoxia, the experimental myocardial ischemia and myocardial enzymes have a good protective effect, and can fight the experimental drug-induced arrhythmia. Clinical trial proved that domestic L-aspartate potassium magnesium salt of hypokalemia and hypokalemia, digitalis poisoning caused by arrhythmia, etc. have a good effect. In Beijing, Tianjin, Liaoning and other provinces and cities in 11 clinical trials, a total of 189 cases, the total effective rate was 77.8%, of which a variety of causes of hypokalemia significant effect, the effective rate of 86.9%, for low potassium And digitalis poisoning caused by arrhythmia, etc., the effective rate was 81.8%, other causes of arrhythmia as a secondary drug also has a certain effect.