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选用Ｗｉｓｔａｒ大鼠皮下注射异丙肾上腺素（ＩＳＰ，５ｍｇ／ｋｇ）造成心肌缺血损伤模型。结果证实缺血心肌线粒体膜有明显损伤，表现在线粒体膜磷脂含量降低，胆固醇含量及胆固醇与磷脂比值增大，Ｃａ￣（２＋）浓度显著增加。这些变化与氧自由基引发的脂质过氧化作用增强相关
Wistar rats were injected subcutaneously with isoproterenol (ISP, 5mg / kg) to induce myocardial ischemia injury model. Results confirmed that myocardial mitochondrial membrane was significantly damaged, showing mitochondrial membrane phospholipid content decreased, cholesterol content and cholesterol and phospholipid ratio increased, Ca ~ (2+) concentration increased significantly. These changes are associated with increased lipid peroxidation induced by oxygen free radicals