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目的比较采用大剂量质子泵抑制剂和H2受体拮抗剂治疗上消化道出血的临床疗效。方法将86例在我院就诊的上消化道出血患者随机分为两组,在常规治疗的基础上,治疗组采用大剂量的奥美拉唑静脉推注,对照组静脉滴注法莫替丁,对两组患者的临床疗效进行比较。结果治疗组有效率为95.4%,明显高于对照组的72.1%,两组比较差异有统计学意义(P<0.01);经治疗后两组的临床症状均有明显改善,治疗组与对照组比较差异有统计学意义(P<0.01)。结论大剂量的奥美拉唑治疗上消化道出血可有效改善患者的临床症状,效果确切,值得临床推广。
Objective To compare the clinical efficacy of high-dose proton pump inhibitor and H2 receptor antagonist in the treatment of upper gastrointestinal bleeding. Methods Eighty-six patients with upper gastrointestinal bleeding in our hospital were randomly divided into two groups. On the basis of routine treatment, the treatment group received high-dose omeprazole intravenous injection, and the control group received intravenous drip of famotidine , The clinical efficacy of two groups of patients were compared. Results The effective rate of the treatment group was 95.4%, which was significantly higher than that of the control group (72.1%), the difference between the two groups was statistically significant (P <0.01); after treatment, the clinical symptoms of both groups were significantly improved, the treatment group and the control group The difference was statistically significant (P <0.01). Conclusion High-dose omeprazole in the treatment of upper gastrointestinal bleeding can effectively improve the clinical symptoms of patients with the exact effect, worthy of clinical promotion.