【摘 要】
：
Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world.After decades of sporadic outbreaks,it re-emerged in Africa,Asia,India Ocean and America suddenly,causing major regional epidemic
【机 构】
：
Viral Disease and Vaccine Translational Research Unit, CAS Key Laboratory of Molecular Virology and
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Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world.After decades of sporadic outbreaks,it re-emerged in Africa,Asia,India Ocean and America suddenly,causing major regional epidemics recently and becoming a notable global health problem.Infection by CHIKV results in a spectrum of clinical diseases including an acute self-limiting febrile illness in most individuals,a chronic phase of recurrent join pain in a proportion of patients,and long-term arthralgia for months to years for the unfortunate few.No specific anti-viral drugs or licensed vaccines for CHIKV are available so far.A better understanding of virus-host interactions is essential for the development of therapeutics and vaccines.To this end,we reviewed the existing knowledge on CHIKV\'s epidemiology,clinical presentation,molecular virology,diagnostic approaches,host immune response,vaccine development,and available animal models.Such a comprehensive overview,we believe,will shed lights on the promises and challenges in CHIKV vaccine development.
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