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目的:观察脑梗死患者血清腐胺、精脒、精胺水平,探讨聚胺代谢紊乱在脑梗死病理生理过程中的作用。方法:选择62例脑梗死患者及26例正常人,应用高效液相色谱法测定血清腐胺、精脒、精胺水平。结果:脑梗死病人发病7天内腐胺水平显著升高并达峰值,7天后开始下降,14天后仍明显高于对照组;精脒、精胺水平7天内显著低于对照组,7天后恢复并逐渐达对照组水平。脑梗死急性期腐胺水平随病情加重显著升高,精脒、精胺水平随病情加重而下降。血清腐胺、精脒、精胺水平变化与脑梗死部位关系不大。结论:聚胺代谢紊乱参与了脑梗死的病理生理过程。
Objective: To observe the levels of serum putrescine, spermidine and spermine in patients with cerebral infarction and to explore the role of polyamine metabolism disorder in the pathophysiology of cerebral infarction. Methods: Sixty-two patients with cerebral infarction and 26 healthy controls were selected. Levels of serum putrescine, spermidine and spermine were determined by high performance liquid chromatography. Results: The levels of putrescine in patients with cerebral infarction increased significantly and reached a peak within 7 days after onset, and began to decline after 7 days. The levels of putrescine and spermine were still significantly lower than those in the control group within 7 days after operation and were recovered after 7 days Gradually reached the control group level. The levels of putrescine and spermine in the acute stage of cerebral infarction increased significantly with the severity of the disease. The levels of spermine and spermine decreased with the severity of the disease. Serum putrescine, spermidine, spermine level changes have little to do with cerebral infarction. Conclusion: Polyamines metabolic disorders are involved in the pathophysiology of cerebral infarction.