缓释型速尿与氨苯蝶啶联合应用的药物动力学和药效学的研究

来源 :国外医学.药学分册 | 被引量 : 0次 | 上传用户:xielinyun
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理想的利尿药应符合下列条件:能按间质水肿液中电解质的比例(Na~+∶K~+=35∶1和Na~+∶Cl~-=1.3∶1)来消除电解质;能消除特定部位的水肿;能很好控制尿的形成,而对电解质平衡及尿酸、葡萄糖和脂肪的代谢无不良作用。因为至今尚无如此理想的利尿药,故联合应用利尿药作为相互补充,老药的合用也会显示此种可能性,例如噻嗪类和氨苯蝶啶联合应用,其 The ideal diuretic should meet the following conditions: the electrolyte in the interstitial edema solution (Na ~ +: K ~ + = 35: 1 and Na ~ +: Cl ~ - = 1.3: 1) to eliminate the electrolyte; Edema at specific sites; good control of urinary formation without adverse effects on electrolyte balance and metabolism of uric acid, glucose and fat. Because so far there is no such ideal diuretic, so the combination of diuretics as a complement to each other, the combination of old drugs will show such possibilities, such as the combination of thiazide and triamterene, which
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