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目的:了解骨科围手术期预防性应用抗菌药,评价应用的合理性。方法:查阅2005年1～12月骨科病历810份,对其中符合围手术期要求的592份病历预防性应用抗菌药物的品种、联合用药、用药时间、切口愈合进行统计分析。结果:骨科围手术期患者抗菌药物总的使用率为97.13%(575例),主要药物种类为β-内酰胺酶抑制剂复方制荆(44.69%)、头孢菌素类(27.83%)、喹诺酮类(23.48%);其中单用、二联和三联用药分别为:93.04%(535例)、6.61%(38例)和0.35%(2例);平均疗程4.89d;手术切口甲级愈合率96.11%(569例)。结论:加强抗菌药物的使用管理,规范围手术期抗菌药物的使用原则,对术后抗感染至关重要。
Objective: To understand the prophylactic use of antibacterials during perioperative orthopedics and to evaluate the rationality of the application. Methods: One hundred and eighty orthopedic medical records from January to December in 2005 were consulted, and 592 medical records of prophylactic antibacterials which were in compliance with perioperative requirements were collected for statistical analysis. Results: The overall use rate of antibiotics in perioperative patients was 97.13% (575 cases). The main drugs were β-lactamase inhibitors (44.69%), cephalosporins (27.83%), quinolones (53.4%), 6.61% (38 cases) and 0.35% (2 cases), respectively. The mean course of treatment was 4.89 days. The rate of grade A healing 96.11% (569 cases). Conclusion: To strengthen the management of the use of antimicrobial agents and to regulate the use of perioperative antibacterials are crucial to postoperative anti-infection.