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目的 :探讨脑神经生长素对新生儿缺血缺氧性脑病(HIE)脑损伤的保护作用。方法 :选取本院新生儿科收治的98例HIE新生儿采用随机数字表法分为试验组和对照组各49例,两组患儿均采用常规治疗,试验组加用脑神经生长素治疗,两组患者均治疗7d后观察临床效果。结果 :治疗后第7d、第14d两组患儿的NBNA评分均显著高于治疗第1d和对照组;试验组患儿治疗3个月、6个月的MDI、PDI评分均显著的高于对照组患儿;试验组患儿治疗有效率81.63%显著高于对照组的63.27%。结论 :脑神经生长素辅助常规疗法对HIE患儿脑损伤具有显著的保护作用,有利于患儿远期智能发育。
Objective: To investigate the protective effect of brain growth factor on brain injury induced by neonatal hypoxic-ischemic encephalopathy (HIE). Methods: A total of 98 HIE newborns admitted to neonatal department of our hospital were randomly divided into trial group and control group, 49 cases in each group. Both groups were treated by conventional therapy. The patients were observed for 7 days after treatment. Results: The NBNA scores of the two groups were significantly higher than those of the first day and the control group on the 7th day and the 14th day after treatment. The MDI and PDI scores of the experimental group at 3 and 6 months after treatment were significantly higher than those of the control Group children; test group children treatment efficiency was significantly higher than the control group of 81.63% 63.27%. CONCLUSION: Cerebral auxins supplemented with routine therapy have a significant protective effect on brain injury in children with HIE, which is good for the long-term intellectual development of children.