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单克隆抗体(monoclonal antibody,McAb)是来自单个B淋巴细胞或一个杂交瘤细胞克隆的只识别某一种特定抗原表位(抗原决定簇)的抗体。1975年Kohler和Milstein[1]共同创立了杂交瘤技术,首次获得了人工制备的单克隆抗体。单克隆抗体具有高度的特异性和均一性,且能大量制备,从而为抗体的研究和应用带来了突破,在疾病的预防、
A monoclonal antibody (McAb) is an antibody that recognizes only a specific epitope (antigenic determinant) from a single B lymphocyte or a hybridoma clone. In 1975 Kohler and Milstein [1] co-founded the hybridoma technology, for the first time obtained by artificial preparation of monoclonal antibodies. Monoclonal antibodies with a high degree of specificity and uniformity, and can be prepared in large quantities, which for the antibody research and application of a breakthrough in disease prevention,