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[目的]以X线胸片为主要观察指标 ,对中西医结合治疗SARS的临床疗效进行客观评价 ,为SARS临床筛选有效的干预方案提出科学依据。[方法]采用多中心前瞻性队列研究的方法 ,通过对参加国家863重大项目“中医结合治疗SARS临床研究”的北京地区11家医院361例确诊SARS患者的1561张X线胸片的研究 ,阐明中西医结合治疗对SARS肺部炎症的影响。[结果]从总体疗效来看 ,X线胸片总积分西医组平均为5.85±6.5。中西医结合组为6.67±7.61;普通型西医组为4.79±5.6。中西医结合组为5.40±6.86;重型西医组为7.67±6.34,中西医结合组为8.16±7.60 ,以上两组间比较均未见显著性差异 (P>0.05)。但发病7d内开始干预的胸片总积分西医组平均为6.39±6.48、中西医结合组为4.40±4.97,中西医结合组X线胸片总积分明显低于西医组 (P=0.0004) ;普通型西医组为4.59±5.22、中西医结合组为3.99±4.67,两组间比较未见显著性差异 (P=0.12) ;重型西医组为9.14±7.24、中西医结合组为5.30±5.48,中西医结合组胸片总积分明显低于西医组 (P=0.034) ;说明发病7d内对SARS患者进行中西医结合治疗 ,肺部炎症的吸收明显优于西医组 ,总体疗效与重型患者的疗效均具有统计学意义。[结论]中西医结合早期干预对SARS肺部炎症吸收的临床疗效具有明显的优势
[Objective] To evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of SARS by taking X-ray as the main observation index, and to provide a scientific basis for effective clinical screening of SARS. [Methods] A multicenter prospective cohort study was conducted to investigate 1561 X-ray films of 361 SARS patients diagnosed in 11 hospitals in Beijing area participating in the national 863 major project “Clinical Study of SARS for Integrative Chinese Medicine” Effect of Integrative Chinese and Western Medicine on Pulmonary Inflammation in SARS. [Results] From the overall effect, the total score of X-ray chest in Western medicine group was 5.85 ± 6.5. Integrative Medicine group was 6.67 ± 7.61; General Western medicine group was 4.79 ± 5.6. Integrative Medicine group was 5.40 ± 6.86; Western medicine group was 7.67 ± 6.34, Integrative Medicine group was 8.16 ± 7.60, no significant difference between the two groups (P> 0.05). However, the total score of the chest X-ray film that began intervention within 7 days after onset was 6.39 ± 6.48 in the Western medicine group and 4.40 ± 4.97 in the Integrative Chinese medicine group, the total score of X-ray was significantly lower than that in the Western medicine group (P = 0.0004) 4.59 ± 5.22 in Western medicine group and 3.99 ± 4.67 in Integrative Medicine group, there was no significant difference between the two groups (P = 0.12), 9.14 ± 7.24 in Severe Western Medicine Group and 5.30 ± 5.48 in Integrative Medicine Group Western medicine combination group was significantly lower than the Western medicine group total score (P = 0.034); within 7d onset of SARS patients with Integrative Medicine, lung inflammation absorption was significantly better than Western medicine group, the overall efficacy and efficacy of heavy patients were has statistical significane. [Conclusion] The clinical efficacy of early intervention with integrated traditional Chinese and western medicine on SARS pulmonary inflammation has obvious advantages