目的探讨辛伐他汀合并氯吡格雷对急性冠脉综合征血脂的影响。方法 64例急性冠脉综合征患者被平分成两组,对照组采用常规治疗,治疗组采用辛伐他汀联用氯吡格雷治疗。结果治疗组与对照组治疗前比较TC、TG、LDL-C、CK水平差异无统计学意义,不过治疗12周后,治疗组TC、TG、LDL-C较用药前与对照组有明显下降(P<0.01);两组CK都无明显升高。两组不良反应情况相比差异无统计学意义(P>0.05)。结论辛伐他汀合并氯吡格雷可通过提高内皮功能,抑制炎症等非降脂作用来发挥治疗急性冠脉综合征,值得临床推广。 Objective To investigate the effect of simvastatin combined with clopidogrel on acute coronary syndromes. Methods Sixty-four patients with acute coronary syndrome were divided into two groups. The control group was treated with conventional therapy. The treatment group was treated with simvastatin combined with clopidogrel. Results There was no significant difference in TC, TG, LDL-C and CK levels between the treatment group and the control group before treatment, but TC, TG and LDL-C in the treatment group decreased significantly after 12 weeks of treatment P <0.01); no significant increase in both CK. Adverse reactions between the two groups showed no significant difference (P> 0.05). Conclusions Simvastatin combined with clopidogrel exerts its therapeutic effect on acute coronary syndromes through enhancing endothelial function and inhibiting non-lipid-lowering effects such as inflammation, which is worthy of clinical promotion.