【摘 要】
：
Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis (RA).In a continuous research aiming at discovery of sinomenine derivates wi
【机 构】
：
Hubei Key Laboratory of Natural Products Research and Development,Institute of Chemical Biology and
【基金项目】
：
the Fundamental Research Funds for Central University;国家自然科学基金
论文部分内容阅读
Sinomenine is a clinically available drug for the treatment of rheumatoid arthritis (RA).In a continuous research aiming at discovery of sinomenine derivates with better bioactivity,a cross-coupling reaction of sinomenine and 1,2-dihydroxybenzene catalyzed by a fungus Coriolus unicolor afforded an unique C-C cross-coupled compound 2,together with (S)-disinomenine and (R)-disinomenine.The structure of 2 was elucidated by MS and NMR spectroscopy.Compound 2 was further assayed for the inhibitory activity on IL-6 overproduction in SW982 cells and exhibited a much more potent activity on IL-6 (96％ inhibition)compared with those of (S)-disinomenine and sinomenine (17％ and 12％ inhibition,respectively).
其他文献
Two perovskite-type fluorides K2NaVF6 and (NH4)3VF6 were synthesized under mild hydrothermal conditions.The structures of the compounds were determined by means
Glutathione transferases(GSTs) play an important role in the detoxification of xenobiotic/endobiotic toxic compounds.The a-,π-,and μ-classes of cytosolic GSTs
In the present paper,the influence of carbon nanofiber on interlaminar fracture toughness of CFRP investigated using MMB(Mixed Mode Bending) tests.Vapor grown c
An effective and accurate method was developed for the extraction of astaxanthin from Laminariajaponica with subsequent separation by ionic liquid-based monolit
Thin films of perovskite manganese oxide La0.66Ca0.29K0.05MnO3(LCKMO) on Au/ITO(ITO=indium tin oxide) substrates were prepared by off-axis radio frequency magne
Cobalt phthalocyanine-graphene (CoPc-Gr) complex are fabricated through π-π interaction of each components,with CoPc adsorbed/inserted on/in the graphene shee
This paper presents a new methodology for coarse-grained atomistic simulation of inelastic material behavior including phase transformations in ceramics and dis
Initial mesoscale vortex effects on the tropical cyclone (TC) motion in a system where three components coexist (i.e.,an environmental vortex (EV),a TC,and meso
Structural properties of nucleobase underlie their ultrafast excited-state dynamics and low fluorescence quantum yields,which cause effectively nonradiative dec
A Pt/WO3/TiO2 catalyst for propane oxidation was prepared by a stepwise wet impregnation method,and was aged at 800℃ for 5 hr.Compared to the sulfate-derived t