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目的:探讨自拟扶正抑癌方配合泰勒宁片(氨酚羟考酮)对于中重度癌性疼痛的镇痛效果以及对患者生存质量和免疫功能的影响。方法:随机将50例中重度癌性疼痛患者分成治疗组25例,对照组25例。治疗组采用自拟扶正抑癌方配合泰勒宁片口服治疗,对照组单用泰勒宁片口服治疗。结果:治疗组与对照疼痛缓解率分别为96%(24/25)和92%(23/25),两组无明显差异(P>0.05);生活质量KPS评分值及T淋巴细胞亚群(CD3+,CD4+,CD8+,CD4+/CD8+)水平均比治疗前有不同程度提高,两组治疗后KPS评分及T淋巴细胞亚群水平的差异均有统计学意义(P<0.05);两组治疗后不良反应程度比较,治疗组明显低于对照组,其差异有显著性意义(P<0.01)。结论:自拟扶正抑癌方可以提高患者生活质量及免疫功能,有效减轻泰勒宁片的不良反应,其配合泰勒宁片治疗中重度癌性疼痛具有较好的临床效果。
Objective: To investigate the analgesic effect of self-made Fangzheng Suppressor in combination with Tyrannin Tablets (CM-oxycodone) on patients with moderate-severe carcinomatous pain and its effects on the quality of life and immune function. Methods: 50 cases of moderate to severe cancer pain were randomly divided into treatment group 25 cases, control group 25 cases. The treatment group with self-right Fangzheng suppressor side treatment with Tyrannin tablets oral treatment, the control group with Tyrannin tablets oral treatment. Results: The pain relief rates in the treatment group and the control group were 96% (24/25) and 92% (23/25) respectively, with no significant difference between the two groups (P> 0.05). The KPS score and T lymphocyte subsets The levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + in all groups were significantly higher than those before treatment (P <0.05). There were significant differences in KPS score and T lymphocyte subsets between the two groups after treatment The degree of adverse reactions, the treatment group was significantly lower than the control group, the difference was significant (P <0.01). CONCLUSION: Self-made Fangzheng Tiaohou decoction can improve the quality of life and immune function of patients and effectively reduce the adverse reaction of Tailing tablets. It has good clinical effect in combination with Tailing tablets in the treatment of moderate-severe cancerous pain.