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益脉降压流浸膏经临床验证治疗老年高血压病气虚血瘀证有确切疗效。为进一步验证其降压效果和探讨其降压机理，对其降压及对内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）的影响进行了实验观察，并与牛黄降压丸对照比较。结果表明益脉降压流浸膏能显著降低自发性高血压大鼠（ＳＨＲ）的血压及ＥＴ，显著升高ＣＧＲＰ，改善ＥＴ／ＣＧＲＰ比值，且高、低剂量组间无显著性差异。上述作用均明显优于牛黄降压丸对照组。由此证明益脉降压流浸膏具有较好的降压及改善血浆ＥＴ、ＣＧＲＰ作用。由此提示纠正ＥＴ、ＣＧＲＰ失调作用可能是其降压的重要机制之一。
Yimai blood pressure flow extract has been clinically proven to treat senile hypertension with qi deficiency and blood stasis syndrome. In order to further verify its antihypertensive effect and explore its hypotensive mechanism, the effect of antihypertensive treatment on endothelin (ET) and calcitonin gene-related peptide (CGRP) was observed and compared with that of Niuhuang Jiangya Pill. . The results showed that Yimai Jiangya extract can significantly reduce blood pressure and ET in spontaneously hypertensive rats (SHR), significantly increase CGRP and improve ET/CGRP ratio, and there was no significant difference between high and low dose groups. The above effects were significantly better than the Niuhuang Jiangya pill control group. This proves that Yimai buck flow extract has better blood pressure and improve plasma ET and CGRP. This suggests that correcting the imbalance of ET and CGRP may be one of the important mechanisms of blood pressure reduction.