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目的探讨早期小剂量使用甲强龙治疗重症急性胰腺炎(SAP)应用价值。方法回顾性分析桂林市人民医院2002年1月至2010年6月在治疗的重症急性胰腺炎患者115例,分为研究组和对照组,两组患者在入院后均予采用重症急性胰腺炎常规综合治疗方案基础上予研究组早期注射甲强龙80mg/d,连续给药2～7d后停药,观察两组多个衡量SAP治疗效果的主要指标的差异。结果研究组在腹痛腹胀缓解时间、血淀粉酶恢复正常时间、血常规白细胞恢复正常时间、腹腔积液消退时间、出现急性肺损伤(ALI)及急性呼吸窘迫综合征(ARDS)等并发症比例、死亡率及平均住院日等衡量SAP治疗效果的主要指标均有明显改善。结论早期小剂量使用甲强龙治疗重症急性胰腺炎效果确定,值得推广。
Objective To investigate the value of early use of methylprednisolone in the treatment of severe acute pancreatitis (SAP). Methods A retrospective analysis of Guilin People’s Hospital in January 2002 to June 2010 in the treatment of 115 cases of severe acute pancreatitis, divided into study group and control group, both groups were admitted to hospital after severe acute pancreatitis conventional Based on the comprehensive treatment plan, the study group was injected with methylprednisolone 80 mg / d in the early stage and discontinued after 2 to 7 days of continuous administration. The differences of the main indexes between the two groups in measuring the effect of SAP treatment were observed. Results In the study group, the proportion of complication such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) were observed in patients with abdominal pain, abdominal pain, abdominal pain, abdominal pain, Mortality and average length of stay and other measures of SAP treatment were significantly improved the main indicators. Conclusions Early use of methylprednisolone in the treatment of severe acute pancreatitis in early small dose is worthy of promotion.