Objective:To investigate the changes in profile of the oxidant and antioxidant indicators throughout pregnancy in goats.Methods: Estrus in goats was synchronized using an intravaginal progestogen impregnated sponge and the buck was introduced in the herd during the experiment for breeding purpose. Serum nitric oxide (NO) as standard angiogenic marker, total antioxidant capacity (TAC) as a cryoprotectant indicator, total peroxide (TPX) as a pathogenetic effector were measured, followed by calculation of OSI% (TPX/TAC)×100 as a reflector of the oxidant/antioxidant status, andmalondialdhyde were estimated.Results:Compared with values in singleton and twins bearing goats, TAC values in multiple bearing goats were higher in 4thmonth and lower in 5th month (P<0.05). Values of TPX were lower in multiple bearing goats in 4th month and higher in 5th month (P<0.05) when compared with singleton and twins bearing goats.In contrary, NO values started to increase from the 2nd month until 4th month of gestation in all pregnant goats. However, the NO was lower in 5th month (P<0.05) in multiple bearing goats.Values of NO were negatively correlated with OSI % in allbearing goats.Conclusion: Knowing the relationship between the fetal number and oxidative stress indicators could be useful in the clinical management of such pregnancies and could be useful in the early detection or prediction adverse pregnancy outcome. Particularly, the 4th and 5th month of gestation increases the liability to reactive oxygen species in goats.