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[目的]通过建立尘肺病患者经纤维支气管镜大容量肺灌洗残余量预测模型,为筛选尘肺肺灌洗对象及初步预测灌洗疗效提供参考。[方法]收集238例尘肺病患者,经纤维支气管镜大容量肺灌洗术,分析残余量与患者病情分期、灌洗量、肺功能、身高、体重、体质指数的关系,建立多元线性回归模型,筛选影响灌洗残余量的主要影响因素。[结果]经纤维支气管镜大容量肺灌洗术中残余量与病情分期无关,不同期别尘肺灌洗量及残余量比较,差异无统计学意义(P>0.05),灌洗量、用力肺活量(FVC%)及50%肺活量最大呼气流量(MEF50)是残余量的影响因素。[结论]本研究建立的经纤维支气管镜大容量肺灌洗残余量预测模型,可初步筛选肺灌洗病人并预测肺灌洗疗效。
[Objective] To establish the prediction model of pulmonary lavage volume in patients with pneumoconiosis by large-volume lung lavage, and to provide a reference for the screening of lavage lung lavage objects and preliminary prediction of lavage efficacy. [Methods] A total of 238 patients with pneumoconiosis were collected. The patients were followed up with large-volume lung lavage by bronchofibroscopy. The relationship between residual volume and patient’s stage, lavage volume, lung function, height, weight and body mass index were analyzed. Multiple linear regression model , Screening the main influencing factors of lavage residual volume. [Results] The residual volume of lung lavage by fiberbronchoscope was not related to the stage of disease. There was no significant difference in the lavage volume and residual volume between different stages of pneumoconiosis (P> 0.05), lavage volume, forced vital capacity (FVC%) and 50% of vital capacity of the maximum expiratory flow (MEF50) is the impact of residual volume. [Conclusion] The predictive model of large-volume lung lavage residual volume established by this study can screen lung lavage patients and predict the efficacy of lung lavage.