笔者对122例青霉素皮试（阳性）患者进行再皮试，同时行生理盐水对照试验，结果119例为阴性，占97．54％，经用青霉素治疗，无1例发生过敏反应。提示青霉素皮试结果与操作者的心理素质、技术因素有密切的关系。因此，对青霉素皮试“阳性”者（曾经发生过青霉素过敏反应者除外），在充分做好抢救工作的前提下，进行再皮试和对照试验具有一定的临床意义。 The author of 122 cases of penicillin skin test (positive) patients with skin test, while saline control test, the results of 119 cases were negative, accounting for 97.54%, with penicillin treatment, no case of anaphylactic reaction. Tip penicillin skin test results and the operator’s psychological quality, technical factors are closely related. Therefore, the penicillin skin test “positive” (who have had allergic reactions except penicillin), under the premise of fully doing the rescue work, the skin test and control trials have some clinical significance.