帕金森病是以涉及基底神经核直接与间接通路功能紊乱为特征的锥体外系疾病 ,后期部分患者伴有黑质外非多巴胺 (dopamine ,DA)能神经元的损伤 ,常伴有痴呆表现 ,严重影响老年人的健康 .由此 ,有关帕金森病病因学与发病机制的研究也成为当前神经科学界关注的热点 ,笔者就这方面的研究进展作一概述 Parkinson’s disease is an extrapyramidal disease characterized by dysfunction of the direct and indirect pathways of the basal ganglia. In the latter part of the patients, dopamine (dopamine, dopaminergic) can damage neurons, often accompanied by dementia, Seriously affecting the health of the elderly.Therefore, the study on the etiology and pathogenesis of Parkinson’s disease has also become the focus of the current neuroscience field, the author of the research progress in this area an overview