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目的应用多普勒超声显像法探讨血管迷走性晕厥(VVS)儿童的血管内皮功能。方法研究对象共20例,均为2002年1月至2003年12月在北京大学第一医院儿科就诊儿童,分为VVS组(n=10)及非VVS对照组(n=10),对10例经直立倾斜试验确诊的血管迷走性晕厥儿童,应用多普勒超声测定肱动脉的血流介导的血管舒张反应,并与10例经直立倾斜试验除外VVS的对照组儿童进行比较。结果两组患儿的年龄、性别、身高、体重、基础血压及基础肱动脉血管内径均无显著性差异,但血管迷走性晕厥儿童的血管内皮依赖性舒张功能较对照组显著增强[(11.93±4.46)%vs(8.46±2.18)%,P<0.05]。结论血管内皮依赖性舒张功能增强可能是儿童血管迷走性晕厥发生机制之一。
Objective To evaluate the vascular endothelial function in children with vasovagal syncope (VVS) using Doppler ultrasound imaging. Methods Twenty patients were included in this study. All of them were pediatric pediatric patients in Peking University First Hospital from January 2002 to December 2003 and were divided into VVS group (n = 10) and non-VVS control group (n = 10) In the case of vasovagal syncope in children diagnosed by eliotropic tilt test, the flow-mediated vasodilation of the brachial artery was measured by Doppler echocardiography and compared with that of 10 control subjects with erected tilt test except for VVS. Results There was no significant difference in age, sex, height, weight, basic blood pressure and basic brachial artery diameter between two groups, but the endothelium-dependent vasodilatation in vasovagal syncope children was significantly higher than that in control group [(11.93 ± 4.46)% vs (8.46 ± 2.18)%, P <0.05]. Conclusion The enhancement of endothelium-dependent vasodilatation may be one of the mechanisms of vasovagal syncope in children.