【摘 要】
：
目的 比较利伐沙班与华法林治疗非瓣膜性心房颤动伴心力衰竭的临床疗效.方法 回顾性分析2018年6月-2019年7月安徽医科大学第二附属医院收治的非瓣膜性心房颤动伴心力衰竭患者118例的临床资料,根据治疗方法不同分为试验组60例和对照组58例.试验组予利伐沙班抗凝治疗,对照组予华法林抗凝治疗.比较2组治疗前后左室射血分数(LVEF)、N末端B型脑钠肽前体(NT-proBNP)、D-二聚体水平;随访1年,比较2组不良事件发生情况.结果 治疗1个月后,2组LVEF均较治疗前升高,NT-proBNP、D-二聚体水
【机 构】
：
230601 合肥市,安徽医科大学第二附属医院心血管内科
论文部分内容阅读
目的 比较利伐沙班与华法林治疗非瓣膜性心房颤动伴心力衰竭的临床疗效.方法 回顾性分析2018年6月-2019年7月安徽医科大学第二附属医院收治的非瓣膜性心房颤动伴心力衰竭患者118例的临床资料,根据治疗方法不同分为试验组60例和对照组58例.试验组予利伐沙班抗凝治疗,对照组予华法林抗凝治疗.比较2组治疗前后左室射血分数(LVEF)、N末端B型脑钠肽前体(NT-proBNP)、D-二聚体水平;随访1年,比较2组不良事件发生情况.结果 治疗1个月后,2组LVEF均较治疗前升高,NT-proBNP、D-二聚体水平均较治疗前降低,且试验组LVEF、NT-proBNP水平变化幅度大于对照组(P＜0.01),但2组D-二聚体水平比较差异无统计学意义(P＞0.05).随访1年,2组全因死亡、栓塞事件及急性心力衰竭发生率比较差异无统计学意义(P＞0.05);试验组出血事件发生率低于对照组(P＜0.05).结论 利伐沙班治疗非瓣膜性心房颤动伴心力衰竭的抗凝效果更佳,在未增加栓塞风险的情况下可显著降低出血风险,改善心功能效果优于华法林,值得临床应用.
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