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[目的]观察扶正固本法联合化疗治疗骨转移癌化疗后白细胞减少症疗效。[方法]使用随机平行对照方法,将56例住院患者按随机数字表法分为两组。化疗同时给予常规止吐等对症治疗。对照组28例单纯化疗。治疗组28例扶正固本法(炙甘草10g,鹿角胶15g,熟地20g,补骨脂15g,川断、茯苓各10g,白术、太子参各15g,当归10g,炙北芪50g);1剂/d,水煎3次混合约300mL,患者开始化疗时即进行中药口服治疗,早晚服用,如果患者出现呕吐、恶心现象,适当减少服用剂量,并增加服用频率。连续治疗30d为1疗程。观测粒细胞集落刺激因子用量、外周白细胞抑制情况、外周白细胞变化情况、不良反应。连续治疗2疗程,判定疗效。[结果]粒细胞集落刺激因子用量治疗组低于对照组(P<0.05)、外周白细胞抑制情况、外周白细胞变化情况治疗组优于对照组(P<0.05)。[结论]扶正固本法联合化疗治疗骨转移癌化疗后白细胞减少症效果显著,值得推广。
[Objective] To observe the efficacy of Fuzheng Guben with chemotherapy in the treatment of leukopenia after chemotherapy for bone metastasis. [Method] Randomized parallel control method was used to divide 56 inpatients into two groups according to the random number table method. Chemotherapy was given symptomatic treatment such as regular antiemetic. The control group received chemotherapy alone. 28 patients in the treatment group were treated with the method of strengthening the body (Bamboo Licorice 10g, antler 15g, rehmannia 20g, psoralen 15g, chuangu, wolfberry each 10g, atractylodes lucidum, heterophylla each 15g, angelica 10g, fubei wolfberry 50g); / d, decoction 3 times mixed about 300mL, the patient started oral chemotherapy of traditional Chinese medicine, sooner or later, if the patient has vomiting, nausea, reduce the dose and increase the frequency of taking. Continuous treatment for 30d is a course of treatment. Observed the amount of granulocyte colony-stimulating factor, peripheral leukocyte inhibition, peripheral leukocyte changes, adverse reactions. Continuous treatment of 2 courses to determine efficacy. [Results] The therapeutic effect of granulocyte colony-stimulating factor in the treatment group was lower than that in the control group (P<0.05), peripheral leukocyte inhibition, and peripheral leukocyte changes. The treatment group was superior to the control group (P<0.05). [Conclusion] Fuzheng Guben combined with chemotherapy was effective in the treatment of leukopenia after chemotherapy for bone metastasis and worthy of promotion.