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为了解医院细菌耐药性 ,采用 17种抗菌药纸片 ,K- B琼脂扩散法对武汉地区 13所大中型医院 6 0岁以上住院患者分离出的致病菌进行耐药性监测 ,结果显示 992株细菌中 2 12株 (2 1.37% )为革兰阳性球菌 ,780株 (78.6 2 % )为革兰阴性杆菌。金葡菌中 42 .86 % (5 4/ 12 6 )耐苯唑西林且呈多重耐药 ,对 89%抗生素耐药 ,对万古霉素均敏感。革兰阴性杆菌中检出绿脓杆菌 197株(2 5 .2 6 % ) ,对亚胺配南、环丙沙星、头孢他啶及阿米卡星耐药率在 10 %以下。大肠杆菌对环丙沙星耐药率高达 6 1% ,17种抗菌药对 992株革兰阳性球菌及革兰阴性杆菌抗菌活性最强者依次为亚胺配南、阿米卡星、头孢他啶、头孢哌酮。
In order to understand the bacterial resistance of the hospital, 17 kinds of antimicrobial paper and K-B agar diffusion method were used to monitor the drug resistance of pathogenic bacteria isolated from inpatients over 60 years old in 13 large and medium-sized hospitals in Wuhan area. The results showed Among the 992 strains, 2 12 (2 1.37%) were Gram-positive cocci and 780 (78.6 2%) were Gram-negative bacilli. Staphylococcus aureus was 42.86% (54/126) resistant to oxacillin and was multi-drug resistant, resistant to 89% antibiotics and susceptible to vancomycin. Ninety-seven strains of Pseudomonas aeruginosa (25.6%) were detected in Gram-negative bacilli. The resistance rate to imipenem, ciprofloxacin, ceftazidime and amikacin was less than 10%. Escherichia coli ciprofloxacin resistance rate as high as 61%, 17 kinds of antibacterials on 992 Gram-positive cocci and Gram-negative bacilli were antibacterial activity followed by imipenem, amikacin, ceftazidime, Cefoperazone.