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鉴于广谱抗菌素、激素和免疫抑制剂的广泛使用,临床上条件致病菌的感染发病率上升等情况,我们曾探讨过I-RNA在抗感染免疫上应用的可能性。实验证明I-RNA能将细胞免疫和噬菌活性传递给正常细胞。正常腹腔细胞被I-RNA致敏后,它们的噬菌功能和细胞内的抑、杀菌作用均呈显著的增强。另一方面,近年来有些在外界分布广、自然抗药性发生率高的革兰氏阴性杆菌(如绿脓杆菌等)引起的感染性疾病逐年增加,并已成为死亡率较高的难治之病,同时像严重烧伤病人由于机
Given the widespread use of broad-spectrum antibiotics, hormones and immunosuppressive agents, and an increased incidence of clinically opportunistic infections, we have explored the potential of I-RNA for anti-infective immunity. Experiments show that I-RNA can deliver cellular immunity and phagocytic activity to normal cells. After normal peritoneal cells were sensitized with I-RNA, their phagocytic function and intracellular inhibitory and bactericidal effects were significantly enhanced. On the other hand, in recent years, some infectious diseases caused by Gram-negative bacilli (such as Pseudomonas aeruginosa, etc.) that are widely distributed and have high natural drug resistance have been increasing year by year and have become refractory to higher mortality At the same time as serious burn patients due to machine