血管活性肠肽瘤是胰岛D1细胞的良性或恶性肿瘤,由于D1细胞分泌大量血管活性肠肽(VIP)而引起严重水泻、低钾血症、胃酸缺乏或胃酸过少。本病是一种非常罕见的内分泌肿瘤,国外报道该病年发病率仅为(0.2～1.0)/100万,有霍乱样严重水泻,不易与其他疾病鉴别。本病的诊断依赖于典型的临床症状和血浆VIP测定,手术切除是最有效的治疗手段。我院肝胆外科近来收治3例VIP瘤,现报告如下。 Vasoactive intestinal peptide neoplasms are benign or malignant tumors of islet D1 cells that cause severe watery diarrhea, hypokalemia, achlorhydria, or hypochlorhydria due to the secretion of large amounts of vasoactive intestinal peptide (VIP) in D1 cells. The disease is a very rare endocrine neoplasms, the incidence of foreign disease reported in the year was only (0.2 to 1.0) / 1 million, cholera-like severe watery, not easy to identify with other diseases. Diagnosis of the disease depends on the typical clinical symptoms and plasma VIP assay, surgical resection is the most effective treatment. Hepatobiliary surgery in our hospital recently treated 3 cases of VIP tumor, are as follows.