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目的探讨胃癌组织中核黄素转运蛋白2(riboflavin transporter-2,RFT2)表达及其与胃癌临床病理参数之间的关系。方法取胃癌石蜡包埋组织标本及癌旁胃黏膜组织标本各60例,用免疫组织化学方法检测癌组织RFT2蛋白表达水平。结果 RFT2蛋白在胃癌组织中的表达水平低于癌旁正常胃黏膜组织(P<0.05)。胃癌组织中RFT2蛋白表达水平在胃癌的分化程度、TNM分期、Lauren组织学分型方面差异有统计学意义(均P<0.05),在患者性别、民族、年龄、有无淋巴结转移、肿瘤大小方面差异无统计学意义(均P>0.05)。结论 RFT2蛋白表达在人胃癌组织中表达显著下降,其表达与肿瘤组织分化程度及TNM分期密切相关。
Objective To investigate the expression of riboflavin transporter-2 (RFT2) in gastric cancer and its relationship with the clinicopathological parameters of gastric cancer. Methods Totally 60 cases of gastric cancer paraffin-embedded tissue specimens and adjacent gastric mucosa tissue specimens were collected. The expression of RFT2 protein in cancer tissue was detected by immunohistochemistry. Results The expression level of RFT2 protein in gastric cancer tissue was lower than that in normal gastric mucosa (P <0.05). The expression of RFT2 protein in gastric cancer was significantly different in the degree of differentiation, TNM stage and Lauren histological type (all P <0.05). There was significant difference in gender, ethnicity, age, lymph node metastasis and tumor size No statistical significance (all P> 0.05). Conclusion The expression of RFT2 protein is significantly decreased in human gastric cancer tissues. The expression of RFT2 protein is closely related to tumor differentiation and TNM stage.