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Objective To observe the effects of electroacupuncture (EA) on plasma levels of endothelin (ET), nitric oxide (NO), and calcitonin gene related peptide (CGRP) in stress rats.Methods 32 SD rats were randomly divided into 4 groups: control group, stress group, EA after stress and stress after EA group. The plasma levels of NO and CGRP were measured by radioimmunoassay methods the level of NO were measured by biochemical methods. Result Compared with control group,NO level of stress group decreased from (22.7± 3.8)μ mol/L to (18.8± 5.2) μ mol/L (P< 0.05), but ET increased from (140± 17) ng/L to(177± 23)ng/L (P< 0.05); compared with stress group, NO level of EA after stress and stress after EA group increased from (18.8± 5.2) μ mol/L to (23.3± 4.1) μ mol/L and (22.9± 4.1) μ mol/L (P< 0.05); CGRP level increased from (145± 6) ng/L to (184± 22) ng/L (P< 0.05); but ET level decreased from (177± 23) ng/L to (134± 8) ng/L,(140± 20) ng/L (P< 0.05),in which CGRP of stress after EA group has no statistic significance.Conclusion EA at zusanli point can increase gastric mucosa blood flow and protect gastric mucosa.Its mechanism may be related to the regulation of plasma level of ET, NO and CGRP.