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目的探讨糖化血红蛋白(HbA1C)、空腹血糖(FBG)与2型糖尿病视网膜病变的关系。方法对89例2型糖尿病患者进行HbA1C、FBG检测及眼底检查或荧光素造影检查。其中糖尿病正常眼底(NDR)组49例,糖尿病视网膜病变(DR)组40例。结果 HbA1C水平有糖尿病视网膜病变组较无视网膜病变组高(t=5.310,P<0.01),HbA1C水平越高,视网膜病变发生率越高(χ2=12.59,P<0.05),HbA1C≥7%时视网膜病变发生率明显升高;而FBG水平DR组与NDR组差异无统计学意义(t=0.438,P>0.05)。结论 HbA1C测定可作为DR发生、发展的重要指标,且将HbA1C控制在7%以下,对预防糖尿病视网膜病变的发生和发展极为重要,降低糖化血红蛋白水平有助于降低视网膜病变的危险。
Objective To investigate the relationship between hemoglobin A1c (HbA1c), fasting blood glucose (FBG) and type 2 diabetic retinopathy. Methods Eighty-nine patients with type 2 diabetes underwent HbA1C, FBG detection and fundus examination or fluorescein angiography. Among them, 49 patients had normal diabetic retinopathy (NDR) and 40 patients had diabetic retinopathy (DR). Results HbA1C levels were higher in patients with diabetic retinopathy than those without retinopathy (t = 5.310, P <0.01). The higher the HbA1C level was, the higher the incidence of retinopathy was (χ2 = 12.59, P <0.05) The incidence of retinopathy was significantly increased; however, there was no significant difference between FBG DR group and NDR group (t = 0.438, P> 0.05). Conclusion The determination of HbA1C can be used as an important index for the occurrence and development of DR. It is very important to prevent the occurrence and development of diabetic retinopathy by controlling HbA1C below 7%. Reducing HbA1c may reduce the risk of retinopathy.