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目的：探讨ＴＣＦ－α在尖锐湿疣（ＣＡ）发病中致细胞增生的作用。方法：采用免疫组化ＳＰ法检测３０例ＣＡ损害中ＩＧＦ－α的原位表达，并以２０例健康男性正常包皮组织作为对照。结果：两组ＴＣＦ－α表达阳性率相同；ＣＡ组ＴＧＦ－α表达阳性者中的表达程度显著高于对照组（Ｐ＜０．００１）；其过度表达率也明显高于对照组（Ｐ＜０．００５）。结论：ＣＡ组织细胞可合成与分泌较多的ＴＧＦ－α，在其发病中作为中间介质发挥致细胞增生的作用。
Objective: To investigate the role of TCF-α in the pathogenesis of condyloma acuminatum (CA). Methods: Immunohistochemical SP method was used to detect the in situ expression of IGF-α in 30 cases of CA lesions and 20 healthy male normal foreskin tissues were used as controls. Results: The positive rate of TCF-α expression was the same in both groups. The expression level of TGF-α in CA group was significantly higher than that in control group (P <0.001). The overexpression rate of TCF-α in CA group was also significantly higher than that in control group (P < 0.005). CONCLUSION: CA tissue cells can synthesize and secrete more TGF-α, play an important role in the pathogenesis of cell proliferation as an intermediate mediator.