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目的观察早餐前口服格列美脲联合睡前皮下注射甘精胰岛素治疗60例2型糖尿病伴磺脲类药物继发失效(secondary failure of sulfonylurea,SFS)患者的效果。方法选择SFS2型糖尿病患者60例,早餐前口服格列美脲联合睡前皮下注射甘精胰岛素治疗12周,观察空腹血糖(FPG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)治疗前后变化的情况。结果 FPG、PBG、HbA1c、TG较治疗前明显下降,P<0.01。结论早餐前口服格列美脲联合睡前皮下注射甘精胰岛素治疗2型糖尿病SFS患者方法简单易行,依从性好,效果显著。
Objective To observe the effect of oral glimepiride combined with glargine administered subcutaneously before bedtime in the treatment of 60 patients with type 2 diabetes and secondary failure of sulfonylurea (SFS). Methods Sixty patients with SFS2 type diabetes mellitus were treated with glimepiride combined with glargine before bedtime for 12 weeks. Fasting blood glucose (FPG), postprandial blood glucose (PBG), hemoglobin A1c (HbA1c) Changes in triglyceride (TG) before and after treatment. Results FPG, PBG, HbA1c, TG were significantly lower than before treatment, P <0.01. Conclusion Pregame oral glimepiride combined with bedtime hypodermic injection of insulin glargine in patients with type 2 diabetes mellitus SFS patients with simple, good compliance, the effect is significant.