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目的:观察satraplatin是否能提高移植性FaDu头颈部鳞癌的放射治疗疗效。方法:建立裸鼠肿瘤模型70只,当位于每只裸鼠右大腿的肿瘤直径达到8．0 mm(7．6～8．3 mm)时开始实验。实验共分成7组(每组10只),分别是对照组、satra- platin组、放疗(radiotherapy,RT)组、satraplatin+RT(6 h后)组、satraplatin+RT(24 h后)组、RT+satraplatin(6 h后)组和RT+satraplatin(24 h后)组。观察指标为肿瘤生长延迟时间(肿瘤直径从8．0 mm生长至12．0 mm所需时间)和肿瘤治愈的情况。结果:3只荷瘤鼠在治疗过程中死亡,其余67只无治愈。观察肿瘤生长情况发现satraplatin组和放疗组的绝对延迟时间分别为(0．7±0．4)d和(5．5±1．1)d,而satraplatin+RT(6 h后)组、satraplatln+RT(24 h后)组、RT+satraplatin(6 h后)组和RT+satraplatin(24 h后)组的绝对延迟时间则分别为(8．1±1．3)、(7．8±1．1)、(6．6±1．1)和(4．3±0．6)d,其标准化的延迟时间分别为(7．4±1．3)、(7．1±1．1)、(5．9±0．6)和(3．6±0．6)d,增益因子分别为1．30、1．25、1．04和0．63。结论:实验结果显示在放疗前6或24 h应用satraplatin能提高移植性FaDu头颈部鳞癌的放射治疗疗效。
Objective: To investigate whether satraplatin can improve the radiotherapy efficacy of transplanted FaDu head and neck squamous cell carcinoma. Methods: Tumor models of 70 nude mice were established, and the experiment was started when the diameter of tumor located in the right thigh of each nude mouse reached 8.0 mm (7.6 ~ 8.3 mm). The experiment was divided into 7 groups (10 in each group), which were control group, satraplatin group, radiotherapy group, satraplatin + RT group after 6 h, satraplatin + RT group after 24 h, RT + satraplatin (after 6 h) and RT + satraplatin (after 24 h). The observation index was the tumor growth delay time (tumor diameter from 8.0 mm to 12.0 mm the time required) and tumor cure. Results: Three tumor-bearing mice died during the treatment, and the remaining 67 were not cured. The absolute delay time of satraplatin group and radiotherapy group was (0.7 ± 0.4) days and (5.5 ± 1.1) days respectively, while the satraplatin + RT group (6 hours later), satraplatln The absolute delay time of RT + satraplatin group (6 h) and RT + satraplatin group (24 h) were (8.1 ± 1.3) and (7.8 ± 1.1, 6.6 ± 1.1 and 4.3 ± 0.6 d, respectively. The normalized delay times were (7.4 ± 1.3) and (7.1 ± 1. 1), (5.9 ± 0.6) and (3.6 ± 0.6) d, with gain factors of 1.30, 1.25, 1.04 and 0.63, respectively. CONCLUSIONS: The experimental results show that satraplatin at 6 or 24 h before radiotherapy can improve the radiotherapy efficacy of transplanted FaDu head and neck squamous cell carcinoma.