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噻苯唑啉琥珀酸盐是第一个报导有抗心律失常作用的咪唑类衍生物,能延长动作电位和有效不应期,减慢其上升速度、延长复极过程、阻滞慢钙内向通道,Vaughan建议划为第三类药物。1980年以来,陆续报导了噻苯唑啉治疗室性心律失常和预激综合征的疗效,长期服用,副作用极少。电生理作用噻苯唑啉的心脏电生理作用包括膜稳定作用,与β受体阻断剂(第二类)相似的减慢传导的作用,以及影响钙离子而轻度抑制心肌收缩力的作用。
Thiazolidine succinate is the first imidazole derivative reported to have anti-arrhythmic action, prolonging action potentials and effective refractory periods, slowing its rate of rise, prolonging repolarization, and blocking slow Ca2 + channels , Vaughan recommended as the third category of drugs. Since 1980, thiazolidinyl one after another reported the efficacy of ventricular arrhythmia and WPW syndrome, long-term use, with very few side effects. Electrophysiological Effects The cardiac electrophysiological effects of thiazolidin include membrane stabilization, a slowing down effect similar to beta blockers (category II), and a mild effect on myocardial contractility by affecting calcium ions .