类固醇受体辅激活因子3(SRC-3)是一类与转录激活有关的蛋白辅助因子,通过与激素激活的核受体和其他一些特定的转录因子结合,参与调控机体的生长发育、能量代谢、细胞增殖、存活以及迁徙等过程。近年来,SRC-3广泛的促瘤作用更成为研究热点。SRC-3蛋白不仅与核受体相互作用,还与多种转录因子结合,通过多条信号通路促进靶基因的转录,进而调控细胞生长、促进细胞增殖,在一些激素相关和非激素相关的癌症中发挥促瘤作用。该文就SRC-3作为促癌因子与肿瘤的相关性及其促增殖途径予以综述。 Steroid receptor coactivator 3 (SRC-3) is a class of protein cofactors that are involved in transcriptional activation and are involved in the regulation of body growth and development, energy metabolism, by binding to hormone-activated nuclear receptors and other specific transcription factors , Cell proliferation, survival and migration processes. In recent years, SRC-3 wide range of tumor-promoting effect has become a research hot spot. SRC-3 protein not only interacts with nuclear receptors, but also binds to a variety of transcription factors and promotes transcription of target genes through multiple signaling pathways, thereby regulating cell growth and promoting cell proliferation. In some hormone-related and non-hormone-related cancers Play a role in promoting tumor. This article reviews the relationship between SRC-3 as a tumor-promoting factor and tumor-promoting pathways.